Anti Inflamatory Herbs

By Heartspring Staff

Ginger extract components suppress induction of chemokine expression in human tissue samples

Arthritis researchers from the Johns Hopkins University, Baltimore, MD, published in a 2005 edition of Journal of Alternative Complementary Medicine how ginger has a long history of medicinal use, particularly as an anti-inflammatory that can act on a variety of diseases, including arthritis. Inflammation reduction in arthritis is attributed to the suppression of pro-inflammatory cytokines and chemokines. The researchers looked at combination ginger extract and its individual components on chemokine expression in human synoviocytes, as well as, extracts containing two types of ginger, Zingiber officinale and Alpinia galanga. This Ginger extract combination was consistently more effective in decreasing chemokine mRNA and chemokine secreted protein levels of Zingiber officinale or Alpinia galanga alone. In comparison, Zingiber officinale was more effective than Alpinia galanga in suppressing chemokine expression. Zingiber officinale and Alpinia galanga components appeared to work synergistically and the researchers cite how this ginger and gangla combination may be useful for suppressing arthritis inflammation.

Ginger - An herbal medicinal with broad anti-inflammatory actions

Journal of Medicinal Food Sept 2005 - "The anti-inflammatory properties of ginger have been known and valued for centuries. During the past 25 years, many laboratories have provided scientific support for the long-held belief that ginger contains constituents with anti inflammatory properties. The original discovery of ginger's inhibitory effects on prostaglandin biosynthesis in the early 1970s has been repeatedly confirmed. This discovery identified ginger as an herbal medicinal product that shares pharmacological properties with non-steroidal anti-inflammatory drugs. Ginger suppresses prostaglandin synthesis through inhibition of cyclooxygenase-1 and cyclooxygenase-2. An important extension of this early work was the observation that ginger also suppresses leukotriene biosynthesis by inhibiting 5-lipoxygenase. This pharmacological property distinguishes ginger from nonsteroidal anti-inflammatory drugs. This discovery preceded the observation that dual inhibitors of cyclooxygenase and 5-lipoxygenase may have a better therapeutic profile and have fewer side effects than non-steroidal anti-inflammatory drugs. The characterization of the pharmacological properties of ginger entered a new phase with the discovery that a ginger extract (EV.EXT.77) derived from Zingiber officinale (family Zingiberaceae) and Alpina galanga (family Zingiberaceae) inhibits the induction of several genes involved in the inflammatory response. These include genes encoding cytokines, chemokines, and the inducible enzyme cyclooxygenase-2. This discovery provided the first evidence that ginger modulates biochemical pathways activated in chronic inflammation. Identification of the molecular targets of individual ginger constituents provides an opportunity to optimize and standardize ginger products with respect to their effects on specific biomarkers of inflammation. Such preparations will be useful for studies in experimental animals and humans."

[6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis (cancer) in vitro and in vivo.

Biochemistry Biophysical Research Communications. 2005 Sep Department of Biochemistry, College of Natural Sciences, Yonsei University, Seoul, Republic of Korea - "[6]-Gingerol, a pungent ingredient of ginger (Zingiber officinale Roscoe, Zingiberaceae), has anti-bacterial, anti-inflammatory, and anti-tumor-promoting activities. Here, we describe its novel anti-angiogenic activity in vitro and in vivo. In vitro, [6]-gingerol inhibited both the VEGF and bFGF induced proliferation of human endothelial cells and caused cell cycle arrest in the G1 phase. It also blocked capillary-like tube formation by endothelial cells in response to VEGF, and strongly inhibited sprouting of endothelial cells in the rat aorta and formation of new blood vessel in the mouse cornea in response to VEGF. Moreover, i.p. administration, without reaching tumor cytotoxic blood levels, to mice receiving i.v. injection of B16F10 melanoma cells, reduced the number of lung metastasis, with preservation of apparently healthy behavior. Taken together, these results demonstrate that [6]-gingerol inhibits angiogenesis and may be useful in the treatment of tumors and other angiogenesis-dependent diseases.




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