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Collection of Research Showing Ashwaghanda's Affect on Human Health

By Staff.

Withanolides are the active ingredient in Ashwaghanda (Withania). Ayurvedic medicines prepared in India consist of Withania somnifera roots (the source of withanolides) as one of the main ingredients. It is consumed as a dietary supplement around the world.

  • In vitro propagation of Withania somnifera and isolation of withanolides with immunosuppressive activity.
    Planta Medicine. 2001 Mar;67(2):146-9. PMID:11301861
  • Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves.
    Life Sci. 2003 Nov 21;74(1):125-32. PMID:14575818
  • Withania somnifera Dunal (Ashwagandha): potential plant source of a promising drug for cancer chemotherapy and radiosensitization.
    Indian Journal of Experimental Biology. 1996 Oct;34(10):927-32. Review. PMID:9055640
  • Novel cytotoxic and antitumor agents. IV. Withaferin A: relation of its structure to the in vitro cytotoxic effects on P388 cells.
    Neoplasma. 1984;31(1):31-6. PMID:6700792

Other Plants Containing Withanolides

  • Cytotoxicity and immunosuppressive activity of withanolides from Discopodium penninervium.
    Planta Medicine. 1997 Feb;63(1):15-7. PMID:9063090
  • 17-Epiacnistin-A, a further withanolide from the leaves of Discopodium penninervium.
    Journal Nat Prod. 2000 Apr;63(4):512-3. PMID:10785427
  • Cytotoxic epimeric withaphysalins from leaves of Acnistus arborescens.
    Planta Medicine. 2004 Jun;70(6):551-5. PMID:15241891



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Updated: Dec 21 2013