Ashwaghanda Research
Page updated: 10-22-2004
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Withanolides are the active ingredient in Ashwaghanda (Withania)

Ayurvedic medicines prepared in India consist of Withania somnifera roots (the source of withanolides) as one of the main ingredients. It is consumed as a dietary supplement around the world.


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 Current Ashwaghanda (Withanolides) Research
Search for Echinacea Research
1: Habtemariam S. Related Articles,
Abstract Cytotoxicity and immunosuppressive activity of withanolides from Discopodium penninervium.
Planta Med. 1997 Feb;63(1):15-7.
PMID: 9063090 [PubMed - indexed for MEDLINE]
2: Furmanowa M, Gajdzis-Kuls D, Ruszkowska J, Czarnocki Z, Obidoska G, Sadowska A, Rani R, Upadhyay SN. Related Articles
Abstract In vitro propagation of Withania somnifera and isolation of withanolides with immunosuppressive activity.
Planta Med. 2001 Mar;67(2):146-9.
PMID: 11301861 [PubMed - indexed for MEDLINE]
3: Jayaprakasam B, Zhang Y, Seeram NP, Nair MG. Related Articles
Abstract Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves.
Life Sci. 2003 Nov 21;74(1):125-32.
PMID: 14575818 [PubMed - indexed for MEDLINE]
4: Habtemariam S, Skelton BW, Waterman PG, White AH. Related Articles
Abstract 17-Epiacnistin-A, a further withanolide from the leaves of Discopodium penninervium.
J Nat Prod. 2000 Apr;63(4):512-3.
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5: Fujimoto H, Nagano J, Yamaguchi K, Yamazaki M. Related Articles
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8: Gunatilaka AA, Samaranayake G, Kingston DG, Hoffmann G, Johnson RK. Related Articles
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11: Devi PU. Related Articles
Abstract Withania somnifera Dunal (Ashwagandha): potential plant source of a promising drug for cancer chemotherapy and radiosensitization.
Indian J Exp Biol. 1996 Oct;34(10):927-32. Review.
PMID: 9055640 [PubMed - indexed for MEDLINE]
12: Fuska J, Fuskova A, Rosazza JP, Nicholas AW. Related Articles
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13: Ehrke MJ, Cohen SA, Mihich E. Related Articles
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18: Ushio Y, Abe H. Related Articles
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Immune System
Nutritional Check List

Source: HealthNotes - Immune Function icon

 

Rated

Nutritional Supplements Herbs
•••

Multiple vitamin-mineral (for elderly people)

Vitamin E (for elderly people)

Andro-
graphis

••

Acidophilus

Beta-carotene

Fish oil (omega-3 fatty acids for critically ill and post surgery patients only)

Glutamine (prevention of post-exercise infection in performance athletes)

Selenium (for elderly people)

Thymus extracts

Vitamin A

Vitamin C

Zinc (for elderly people)

Ashwa-
gandha
icon
[Purchase]

Ginseng

Echinacea

Eleuthero

Beta-glucan

Cordyceps

DHEA

Lycopene

Vitamin B12

Whey protein

Zinc (for non-elderly people)

Astragalus

Cat's claw

Fo-ti

Green tea

Ligustrum

Maitake

Noni

••• Reliable and relatively consistent scientific data showing a substantial health benefit.

•• Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.

• An herb is primarily supported by traditional use, or the herb or supplement has little scientific support and/or minimal health benefit.



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Echinacea tea blend shortens duration of cold symptoms

In a double-blind, placebo-controlled clinical study of 95 people, treatment with an echinacea tea preparation (Echinacea Plus®, Traditional Medicinals) early in the course of a cold or flu was significantly more effective in relieving symptoms than a placebo tea. For the 90-day study, participants reported for assignment to one of two treatment groups at the first onset of cold and flu symptoms (scratchy throat, runny nose, fever, etc.). The subjects drank 5 to 6 cups a day of echinacea or placebo tea on the first day of symptoms, reducing the dosage to 1 cup per day for the next five days. Results were assessed with a questionnaire that measured symptom relief, duration of symptoms, and time before subjects noticed a difference in symptoms. The echinacea tea was significantly more effective than placebo in all parameters measured. No side effects were reported in either group. Echinacea Plus is a proprietary blend of E. purpurea and E. angustifolia leaves, flowers, and stems, a water soluble dry extract of E. purpurea root, and flavoring herbs. Eater's Digest® (Traditional Medicinals) was selected as the placebo tea because it was not expected to have a significant effect on cold or flu symptoms at the dosages used in this study. Among other herbs, Eater's Digest contains cinnamon, ginger, and peppermint. Lindenmuth GF, Lindenmuth EB.

The efficacy of echinacea compound herbal tea preparation on the severity and duration of upper respiratory and flu symptoms: a randomized, double-blind placebo-controlled study.

This article originally appeared in The Journal of Alternative and Complementary Medicine 2000; 6(4): 327-334.

 

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