A Review of Mood and Brain Health Research

By Wendy Wells, NMD.


A study by the George Eby Research Institute, published in the Journal of Medical Hypothesis, reports, "Since inadequate brain magnesium appears to reduce serotonin levels, and since anti-depressants have been shown to have the action of raising brain magnesium, we further hypothesize that magnesium treatment will be found beneficial for nearly all depressives and treatment resistant depression."
PMID 19944540Exit Site

Symptoms of possible magnesium deficiency syndrome (Hypomagnesemia) include:

Altered immune responsesExit Site, alcoholismExit Site, arrhythmiasExit Site, asthmaExit Site, ataxiaExit Site, attention deficit hyperactivity disorderExit Site (ADHD), chronic fatigue syndromeExit Site (CFS), circulatory disturbances (arteriosclerosis, cardiac infarction, strokeExit Site), premenstrual crampsExit Site (PMS), depressionExit Site, diabetes mellitusExit Site, epilepsyExit Site, hypertensionExit Site, migraineExit Site, neurodegenerative disorders, multiple sclerosisExit Site (MS), obesityExit Site, osteoporosis, Parkinson's, preeclampsia, stress dependent disorders, tinnitusExit Site

IntraCellular Magnesium

Mg Citrate and Mg Oxide, among others, are incapable of intracellular absorption. See: Magnesium. What's the best kind?

Magnesium: An Essential Mineral for Optimal Health

Department of Family Medicine, University of Connecticut School of MedicineExit Site

Research has shown that the mineral content of magnesium in food sources is declining, and that magnesium depletion has been detected in persons with some chronic diseases. This has led to an increased awareness of proper magnesium intake and its potential therapeutic role in a number of medical conditions. Studies have shown the effectiveness of magnesium in eclampsia and preeclampsia, arrhythmia, severe asthma, and migraine. Other areas that have shown promising results include lowering the risk of metabolic syndrome, improving glucose and insulin metabolism, relieving symptoms of dysmenorrhea, and alleviating leg cramps in women who are pregnant. The use of magnesium for constipation and dyspepsia are accepted as standard care despite limited evidence. Although it is safe in selected patients at appropriate dosages, magnesium may cause adverse effects or death at high dosages. Because magnesium is excreted renally, it should be used with caution in patients with kidney disease. Food sources of magnesium include green leafy vegetables, nuts, legumes, and whole grains. PMID:19621856Exit Site

Proper Breathing: Lowers CO2 - Increases Mg2

Anxiety and respiratory patterns: their relationship during mental stress and physical load. PMID 9342646Exit Site

Central respiratory chemosensitivity is an essential mechanism that, via regulation of breathing, maintains constant levels of blood and brain pH and partial pressure of CO2. PMID 20647426Exit Site

Increased brain-pCO2, acidic cytosol pH and/or increased basal cytosolic Ca2+ level diminish inward Ca2+-current into cytosol, decrease arousal--they may cause dysthymia or depression. This state usually co-exists with ATP-deficiency and decreased cytosolic Mg2+ content. PMID 20128395Exit Site

Coexisting Issues - Allergies and Mental Health

A magnesium-deficient brain is also more susceptible to allergens, foreign substances that can cause symptoms similar to mental illness disorder. http://drcarolyndean.com/magnesium_miracle/Exit Site

Wendy Wells

Author Wendy Wells is a licensed naturopathic physician in the state of Arizona.
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