Tree Bark and Skin Cancer
By Wendy Wells, NMD.
Japanese scientists at Kindai University, Pharmaceutical Research and Technology Institute, diagram molecular pathways among a chemical class called stilbenoids contained in Temak tree bark. A modified group of stilbene, stilbenoids have been show to significantly suppress skin cancer progress via interacellular signaling:
- Hemsleyanol D
- (+)-α-Viniferin 
Temak tree bark Shorea roxburghii, includes protective molecules, called stilbenoids, shown to interrupt melanoma skin cancer in human cell research trials.
Temak grows primarily in Cambodia, India, Laos, Malaysia, Burma, Thailand, and Vietnam, currently on IUCN's Red List of Threatened Species .
Plant Stilbenoids Occur In:
- Blueberry (Cyanococcus),(Pterostilbene) 
- Grape Skin (Vitis vinifera), (Resveratrol) 
- Spruce Bark (Picea abies), (Piceatannol) 
"Piceatannol also has other health promoting and disease preventing functions, such as anti-obese, antidiabetic, neuroptotective, cardioprotective, anti-allergic, anti-aging properties." - College of Pharmacy, Seoul National University 
Besides plant defense against microbial invaders, stilbenes are a class of polyphenols, exhibiting antioxidative and anti-inflammatory activities that modulate molecular targets and signaling pathways of human cancer cells.
"Hemsleyanol D, (+)-α-viniferin, and resveratrol significantly decreased the expression of cyclin B1, which could also suppress cell cycle progression." Biological and Pharmaceutical Bulletin
Five Natural Polyphenols:
- Flavonoids - Iso flavones from soy
- Phenolic Acids - Polyphenol, epigallocatechin gallate (EGCG) from green tea
- Lignans - Flaxseed, Seasame
- Stilbenes - Tree bark, Ptero stilbenoid from blueberries, Resveratrol from grapes
Polyphenols demonstrate anti-antioxidant and anti-inflammatory activities, modulating molecular targets and signaling pathways, associated with cell survival, proliferation, differentiation, migration, angiogenesis (development of new blood vessels), hormone activities, detoxification enzymes, anti-cancer and immune responses. 
Skin Cancer Remedies Phytochemical components found in several herbal remedies.