Tree Bark and Skin Cancer

Temak tree leaf, seeds, and bark
X Temak tree leaf, seeds, and bark

Temak shorea Seeds, Leaf, and Bark

By Wendy Wells, NMD.

Japanese scientists at Kindai University, Pharmaceutical Research and Technology Institute, diagram molecular pathways among a chemical class called stilbenoids contained in Temak tree bark. A modified group of stilbene, stilbenoids have been show to significantly suppress skin cancer progress via interacellular signaling:

Temak tree bark Shorea roxburghii, includes protective molecules, called stilbenoids, shown to interrupt melanoma skin cancer in human cell research trials.

Temak grows primarily in Cambodia, India, Laos, Malaysia, Burma, Thailand, and Vietnam, currently on IUCN's Red List of Threatened Species [2].

Plant Stilbenoids Occur In:

"Piceatannol also has other health promoting and disease preventing functions, such as anti-obese, antidiabetic, neuroptotective, cardioprotective, anti-allergic, anti-aging properties." - College of Pharmacy, Seoul National University [6]

Besides plant defense against microbial invaders, stilbenes are a class of polyphenols, exhibiting antioxidative and anti-inflammatory activities that modulate molecular targets and signaling pathways of human cancer cells.

Stilbenoid cycle "Hemsleyanol D, (+)-α-viniferin, and resveratrol significantly decreased the expression of cyclin B1, which could also suppress cell cycle progression." Biological and Pharmaceutical Bulletin

Five Natural Polyphenols:

Polyphenols demonstrate anti-antioxidant and anti-inflammatory activities, modulating molecular targets and signaling pathways, associated with cell survival, proliferation, differentiation, migration, angiogenesis (development of new blood vessels), hormone activities, detoxification enzymes, anti-cancer and immune responses. [8]

1. Inhibitory Effects of Oligostilbenoids from the Bark of Shorea roxburghii on Malignant Melanoma Cell Growth: Implications for Novel Topical Anticancer Candidates. PMID:27725445

2. IUCN Red List of Threatened Species

3. The resveratrol analogue trimethoxystilbene inhibits cancer cell growth by inducing multipolar cell mitosis. PMID:27739192

4. Muscadine Grape Skin Extract Induces an Unfolded Protein Response-Mediated Autophagy in Prostate Cancer Cells: A TMT-Based Quantitative Proteomic Analysis. PMID:27755556

5, 6. Therapeutic Potential and Molecular Targets of Piceatannol in Chronic Diseases. PMID:27671818

7. Inhibitory Effects of Oligostilbenoids from the Bark of Shorea roxburghii on Malignant Melanoma Cell Growth: Implications for Novel Topical Anticancer Candidates Jstage

8. Natural Polyphenols for Prevention and Treatment of Cancer PMID:4997428




Wendy Wells

Author Wendy Wells is a licensed naturopathic physician in the state of Arizona.
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