Xanthone Research

Mangosteen Fruit - A Source of Xanthones

15546251">Nabandith V, Suzui M, Morioka T, Kaneshiro T, Kinjo T, Matsumoto K, Akao Y, Iinuma M, Yoshimi N.

Inhibitory effects of crude alpha-mangostin, a xanthone derivative, on two different categories of colon preneoplastic lesions induced by 1, 2-dimethylhydrazine in the rat.
Asian Pacific Journal of Cancer Prevention. 2004 Oct-Dec;5(4):433-8.
PMID:15546251

Matsumoto K, Akao Y, Yi H, Ohguchi K, Ito T, Tanaka T, Kobayashi E, Iinuma M, Nozawa Y.

Preferential target is mitochondria in alpha-mangostin-induced apoptosis in human leukemia HL60 cells.
Bioorg Med Chemistry. 2004 Nov 15;12(22):5799-806.
PMID:15498656

Hay AE, Helesbeux JJ, Duval O, Labaied M, Grellier P, Richomme P.

Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii.
Life Sci. 2004 Nov 5;75(25):3077-85.
PMID:15474559

Nakatani K, Yamakuni T, Kondo N, Arakawa T, Oosawa K, Shimura S, Inoue H, Ohizumi Y. gamma-Mangostin inhibits inhibitor-kappaB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells.
Molecular Pharmacology. 2004 Sep;66(3):667-74.
PMID:15322259

Nakatani K, Yamakuni T, Kondo N, Arakawa T, Oosawa K, Shimura S, Inoue H, Ohizumi Y.

gamma-Mangostin Inhibits IkappaB Kinase Activity and Decreases Lipopolysaccharide-Induced Cyclooxygenase-2 Gene Expression in C6 Rat Glioma Cells.
Molecular Pharmacology. 2004 Jun 24;
PMID:15218091

Sato A, Fujiwara H, Oku H, Ishiguro K, Ohizumi Y. Alpha-mangostin induces Ca2+-ATPase-dependent apoptosis via mitochondrial pathway in PC12 cells.
Journal of Pharmacological Sci. 2004 May;95(1):33-40.
PMID:15153648

Hamada M, Iikubo K, Ishikawa Y, Ikeda A, Umezawa K, Nishiyama S.

Biological activities of alpha-mangostin derivatives against acidic sphingomyelinase.
Bioorg Med Chemistry Lett. 2003 Oct 6;13(19):3151-3.
PMID:12951083

Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y. Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines.
Journal of Nat Prod. 2003 Aug;66(8):1124-7.
PMID:12932141

Nakatani K, Nakahata N, Arakawa T, Yasuda H, Ohizumi Y.

Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells.
Biochemistry Pharmacology. 2002 Jan 1;63(1):73-9.
PMID:11754876

Mahabusarakam W, Proudfoot J, Taylor W, Croft K. Inhibition of lipoprotein oxidation by prenylated xanthones derived from mangostin.
Free Radical Research. 2000 Nov;33(5):643-59.
PMID:11200095

Okudaira C, Ikeda Y, Kondo S, Furuya S, Hirabayashi Y, Koyano T, Saito Y, Umezawa K.

Inhibition of acidic sphingomyelinase by xanthone compounds isolated from Garcinia speciosa.
Journal of Enzyme Inhib. 2000;15(2):129-38.
PMID:10938539

Lu ZX, Hasmeda M, Mahabusarakam W, Ternai B, Ternai PC, Polya GM. Inhibition of eukaryote protein kinases and of a cyclic nucleotide-binding phosphatase by prenylated xanthones.
Chemical Biological Interactions. 1998 Jul 3;114(1-2):121-40.
PMID:9744560

Hopert AC, Beyer A, Frank K, Strunck E, Wunsche W, Vollmer G.

Characterization of estrogenicity of phytoestrogens in an endometrial-derived experimental model.
Environmental Health Perspect. 1998 Sep;106(9):581-6.
PMID:9721258

Chairungsrilerd N, Furukawa K, Tadano T, Kisara K, Ohizumi Y. Effect of gamma-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in 5-fluoro-alpha-methyltryptamine-induced head-twitch responses of mice.
British Journal of Pharmacology. 1998 Mar;123(5):855-62.
PMID:9535013

Vlietinck AJ, De Bruyne T, Apers S, Pieters LA.

Plant-derived leading compounds for chemotherapy of human immunodeficiency virus (HIV) infection.
Planta Medicine. 1998 Mar;64(2):97-109. Review.
PMID:9525100

Furukawa K, Chairungsrilerd N, Ohta T, Nozoe S, Ohizumi Y.[Novel types of receptor antagonists from the medicinal plant Garcinia mangostana]
Nippon Yakurigaku Zasshi. 1997 Oct;110 Suppl 1:153P-158P. Japanese.
PMID:9503424

Likhitwitayawuid K, Phadungcharoen T, Krungkrai J.

Antimalarial xanthones from Garcinia cowa.
Planta Medicine. 1998 Feb;64(1):70-2.
PMID:9491769

Chairungsrilerd N, Furukawa KI, Ohta T, Nozoe S, Ohizumi Y. Gamma-mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist.
Naunyn Schmiedebergs Archive Pharmacology. 1998 Jan;357(1):25-31.
PMID:9459569

Gopalakrishnan G, Banumathi B, Suresh G.

Evaluation of the antifungal activity of natural xanthones from Garcinia mangostana and their synthetic derivatives.
Journal of Nat Prod. 1997 May;60(5):519-24.
PMID:9213587

Chairungsrilerd N, Furukawa K, Ohta T, Nozoe S, Ohizumi Y. Pharmacological properties of alpha-mangostin, a novel histamine H1 receptor antagonist.
European Journal of Pharmacology. 1996 Oct 31;314(3):351-6.
PMID:8957258



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Plant Remedies Research
Collection of peer-reviewed and published academic papers.