Nutraceutical Supplement Research

By Heartspring Staff

Sea Vegetable Extracts - Fucoidans, Alginates, Laminarines

Polysaccharide found in the seaweed kombu, U-fucoidan, discovered to cause cancer cells to self-destruct Biomedical Research Laboratories of Takara Shuzo (CEO Hisashi Omiya) and Research Institute for Glycotechnology Advancement, a company funded by the Bio-oriented Technology Research Institute (CEO: Kazue Fukushi), have discovered that a polysaccharide known as U-fucoidan, which is found in kombu and other types of brown seaweed (wakame, mozuku, Limu and hijiki), causes various types of established cancer cell lines to self-destruct. - www.takara-bio.co.jp

Fucoidans role in macrophage stimulation.
Mytar B, Woloszyn M, Macura-Biegun A, Hajto B, Ruggiero I, Piekarska B, Zembala M. Anticancer Research. 2004 Jul- Aug;24(4):2287-93. PMID:15330174

Anti-tumor activity and immune response of fucoidan.
Maruyama H, Tamauchi H, Hashimoto M, Nakano T. In Vivo. 2003 May-Jun;17(3):245-9. PMID:12929574

Preventive effects of fucoidan against Helicobacter pylori infection.
Shibata H, Iimuro M, Uchiya N, Kawamori T, Nagaoka M, Ueyama S, Hashimoto S, Yokokura T, Sugimura T, Wakabayashi K. Helicobacter. 2003 Feb;8(1):59-65. PMID:12603617

Fucoidan expresses anti-tumor properties.
Koyanagi S, Tanigawa N, Nakagawa H, Soeda S, Shimeno H. Biochemistry Pharmacology. 2003 Jan 15;65(2):173-9. PMID:12504793

Fucoidan studied in breast cancer.
Liu JM, Haroun-Bouhedja F, Boisson-Vidal C. Anticancer Research. 2000 Sep-Oct;2000(5A):3265-71. PMID:11062752

Fucoidans block angiogenesis, and prevent tumor spread.
Zugmaier G, Favoni R, Jaeger R, Rosen N, Knabbe C. Ann N Y Acad Sci. 1999;886:243-8. PMID:10667230

Anti-tumor and anti-proliferative effects of a fucoidans.
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Fucoidan inhibits lung metastasis.
Itoh H, Noda H, Amano H, Ito H. Anticancer Research. 1995 Sep- Oct;15(5B):1937-47. PMID:8572581

Anti-tumor active fucoidan from the brown seaweed.
Zhuang C, Itoh H, Mizuno T, Ito H. Biosci Biotechnol BioChemistry. 1995 Apr;59(4):563-7. PMID:7772818

Fucoidan inhibits lung carcinoma.
Soeda S, Ishida S, Shimeno H, Nagamatsu A. Japan Journal of Cancer Research. 1994 Nov;85(11):1144-50. PMID:7829400

Antimetastetic effect of fucoidan.
Soeda S, Ishida S, Honda O, Shimeno H, Nagamatsu A. Cancer Lett. 1994 Sep 30;85(1):133-8. PMID:7923097

Anti-tumor activity of fucoidan.
Itoh H, Noda H, Amano H, Zhuaug C, Mizuno T, Ito H. Anticancer Research. 1993 Nov-Dec;13(6A):2045-52. PMID:8297113

Anti blood clotting and antimetastetic effect of fucoidan.
Maruyama H, Nakajima J, Yamamoto I. Kitasato Archive Experimental Medicine. 1987 Sep;60(3):105-21. No abstract available. PMID:2455094

Anti-tumor activity of fucoidan.
Chida K, Yamamoto I. Kitasato Archive Experimental Medicine. 1987 Jun;60(1- 2):33-9. No abstract available. PMID:3669501

Inhibition of tumor metastasis.
Coombe DR, Parish CR, Ramshaw IA, Snowden JM. International Journal of Cancer. 1987 Jan 15;39(1):82-8. PMID:2878892

Anti-tumor effect of seaweeds.
Yamamoto I, Takahashi M, Suzuki T, Seino H, Mori H. Japan Journal of Experimental Medicine. 1984 Aug;54(4):143-51. PMID:6513098

Laminaria and mammary (breast) cancer in rats.
Teas J, Harbison ML, Gelman RS. Cancer Research. 1984 Jul;44(7):2758-61. PMID:6426785

Fucoidan ad brain lesions.
da Cruz LA, Cruz TF, Moscarello MA. Cell Adhes Communications. 1993 May;1(1):9-20. PMID:7521750

Laminaria japonica converts inorganic minerals into organic minerals.
Yan X, Zheng L, Chen H, Lin W, Zhang W. Journal of Agricultural Food Chemistry. 2004 Oct 20;52(21):6460-6464. PMID:15479007

Laminaria japonica protects liver in induced diabetes.
Jin DQ, Li G, Kim JS, Yong CS, Kim JA, Huh K. Biological Pharm Bulletin. 2004 Jul;27(7):1037-40. PMID:15256736

Effects of fucoidan on chronic renal failure in rats.
Zhang Q, Li Z, Xu Z, Niu X, Zhang H. Planta Medicine. 2003 Jun;69(6):537-41. PMID:12865973

Laminaria expresses antibacterial activity.
Colin C, Leblanc C, Wagner E, Delage L, Leize-Wagner E, Van Dorsselaer A, Kloareg B, Potin P. Journal of Biological Chemistry. 2003 Jun 27;278(26):23545-52. Epub 2003 Apr 15. PMID:12697758

Fucoidans from Laminaria inhibits the human T cell lymphotropic virus.
Romanos MT, Andrada-Serpa MJ, Mourao PA, Yoneshigue- Valentin Y, Costa SS, Pereira MS, Miranda MM, Goncalves JL, Wigg MD. Antiviral Chemicals and Chemotherapy. 2002 Jul;13(4):219-21. PMID:12495209

Free-radical scavenging effect of Laminaria japonica.
Han J, Kang S, Choue R, Kim H, Leem K, Chung S, Kim C, Chung J. Fitoterapia. 2002 Dec;73(7-8):710-2. PMID:12490237

Free-radical scavenging effect of Laminaria japonica.
Kupper FC, Muller DG, Peters AF, Kloareg B, Potin P. Journal of Chemical Ecology. 2002 Oct;28(10):2057-81. PMID:12474900

Alginate affects on blood sugar in humans with diabetes.
Torsdottir I, Alpsten M, Holm G, Sandberg AS, Tolli J. Journal of Nutrition. 1991 Jun;121(6):795-9. PMID:1851824

Alginates bind heavy metals.
Arica MY, Bayramoglu G, Yilmaz M, Bektas S, Genc O. Journal of Hazard Mater. 2004 Jun 18;109(1-3):191-9. PMID:15177759

Alginate for chronic wounds.
Ziegler UE, Schmidt K, Keller HP, Thiede A. Fortschr Med Orig. 2003;121(1):19-26. German. PMID:15117065

Alginates bind heavy metals.
Davis TA, Llanes F, Volesky B, Diaz-Pulido G, McCook L, Mucci A. Applied Biochemistry Biotechnol. 2003 Aug;110(2):75-90. PMID:14515023

Alginates bind heavy metals.
Pandey AK, Pandey SD, Misra V, Devi S. Journal of Hazard Mater. 2003 Mar 17;98(1-3):177-81. PMID:12628785

Fucoidan may benefit diabetics.
Tamura Y, Adachi H, Osuga J, Ohashi K, Yahagi N, Sekiya M, Okazaki H, Tomita S, Iizuka Y, Shimano H, Nagai R, Kimura S, Tsujimoto M, Ishibashi S. Journal of Biological Chemistry. 2003 Apr 11;278(15):12613-7. Epub 2002 Dec 06. PMID:12473645

Sea weeds supplementation lowers blood glucose and supports antioxidant systems in rats.
Lee KS, Choi YS, Seo JS. Journal of Medicinal Food. 2004 Summer;7(2):130-5. PMID:15298757

Nutraceuticals Resources

Nutraceuticals World
Nutraceuticals World is a bimonthly trade magazine focusing on manufacturers of dietary supplements, functional foods and nutritional beverages.

The Nutraceutical Institute Nutraceutical Overview, Rutgers, The State University of New Jersey and St. Joseph's, Philadelphia's Jesuit University

American Nutraceutical Association Develops and provides educational materials and programs on nutraceuticals and nutrition for health care professionals, consumers.

Glyconutrients Research

Glyconutrients and diabetics.
Lloyd P;Hockaday TD;Randle PJ Diabetologia. 1984 Oct; 27: 433-436.

Glyconutrients benefit diabetics.
Morgan LM;Wright JW;Marks V;. Diabetologia. 1979 Apr; 16: 235-239.

Glyconutrients' effect carbohydrate transport in humans.
Martin A;Rambal C;Berger V;. Biochimie. 1998; 80: 75-86.

Glyconutrients' effect carbohydrate transport in rats.
Sykes S;Morgan LM;English J;Marks V;. Journal of Endocrinol. 1980 May; 85: 201-207.

Glyconutrients stimulate macrophage activity.
Takata I;Chida K;Gordon MR;. Journal of Leukoc Biology. 1987 Mar; 41: 248-256.

Glyconutrients effect on metastatic tumors.
Warczynski P;Gil J;Szmigielski S;Beuth J;Pulverer G;. Anticancer Research. 1997 Mar; 17: 1223-1226.

Glyconutrients' effect on metastatic liver tumors.
Isenberg J;Stoffel B;Stutzer H;Otte K;Beuth J;. Anticancer Research. 1997 Sep; 17: 3767-3772.

Glyconutrients effect on metastatic liver tumors.
Kelly GS;. Alternative Medicine Review. 1999 Apr; 4: 96-103.

Lo Han Kuo

Lo Han Kuo - possesses many advantages.
Mu J. Zhonghua Kou Qiang Yi Xue Za Zhi. 1998 May;33(3):183-5. Chinese. PMID:11774428

Lo Han Kou -effectively inhibited Epstein-Barr Virus.
Ukiya M, Akihisa T, Tokuda H, Toriumi M, Mukainaka T, Banno N, Kimura Y, Hasegawa J, Nishino H.
Journal Agricultural Food Chemistry. 2002 Nov 6;50(23):6710-5. PMID:12405766

Research on Cranberry

A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines.
Ferguson PJ, Kurowska E, Freeman DJ, Chambers AF, Koropatnick DJ. Journal of Nutrition. 2004 Jun;134(6):1529-35. PMID:15173424

Cranberry extract effective in urinary tract infections.
Waites KB, Canupp KC, Armstrong S, DeVivo MJ. Journal of Spinal Cord Medicine. 2004;27(1):35-40. PMID:15156935

Cranberry extract effects against human tumor cells.
Seeram NP, Adams LS, Hardy ML, Heber D. Journal of Agricultural Food Chemistry. 2004 May 5;52(9):2512-7. PMID:15113149

Cranberry extract shows antioxidant, and anti-carcinogenic properties.
Bagchi D, Sen CK, Bagchi M, Atalay M. Biochemistry (Mosc). 2004 Jan;69(1):75-80. PMID:14972022

Cranberry extract shows antioxidant, and anti-carcinogenic properties.
Yan X, Murphy BT, Hammond GB, Vinson JA, Neto CC. Journal of Agricultural Food Chemistry. 2002 Oct 9;50(21):5844-9. PMID:12358448

Cranberry extract reduced attachment of E coli.
Allison DG, Cronin MA, Hawker J, Freeman S. Journal of Basic Microbiology. 2000;40(1):3-6. PMID:10746194

Cranberry extract strong antioxidant.
Wilson T, Porcari JP, Harbin D. Life Sci. 1998;62(24):PL381-6. PMID:9627085

Cranberry extract, potential anti cancer property.
Bomser J, Madhavi DL, Singletary K, Smith MA. Planta Medicine. 1996 Jun;62(3):212-6. PMID:8693031

Elderberry Extract

Elderberry extract, an efficient, safe and cost-effective treatment for influenza.
Zakay-Rones Z, Thom E, Wollan T, Wadstein J. Journal of International Med Research. 2004 Mar-Apr;32(2):132-40. PMID:15080016

Elderberry extract - effective against Influenza A and B.
Zakay-Rones Z, Varsano N, Zlotnik M, Manor O, Regev L, Schlesinger M, Mumcuoglu M. Journal of Alternative Complementary Medicine. 1995 Winter;1(4):361-9. PMID:9395631

Elderberry significant decreased cholesterol.
Murkovic M, Abuja PM, Bergmann AR, Zirngast A, Adam U, Winklhofer-Roob BM, Toplak H. European Journal of Clinical Nutrition. 2004 Feb;58(2):244-9. PMID:14749743

Elderberry extract offers an anti-inflammatory benefit.
Barak V, Birkenfeld S, Halperin T, Kalickman I. Isr Med Association Journal. 2002 Nov;4(11 Suppl):919-22. PMID:12455180

Elderberry extract powerful antioxidant.
Roy S, Khanna S, Alessio HM, Vider J, Bagchi D, Bagchi M, Sen CK. Free Radical Research. 2002 Sep;36(9):1023-31. PMID:12448828

Anecdotal reports: Elderberry reduces viral of HIV load to non-detectable levels.
[No authors listed] Posit Health News. 1998 Fall(No 17):7-11. PMID:11366557

Elderberry extract antioxidant.
Youdim KA, Martin A, Joseph JA. Free Radical Biological Medicine. 2000 Jul 1;29(1):51-60. PMID:10962205

Lotus Seed

Lotus seed has unique properties to repair itself even in dark, dry places.
Ushimaru T, Hasegawa T, Amano T, Katayama M, Tanaka S, Tsuji H. Journal of Plant Physiology. 2003 Mar;160(3):321-4. PMID:12749089

Immune System Support

In the age of "super bugs" and stress related illness, a healthy immune system has never been more important. research gives evidence to their immune enhancing effects of Limu and Colostrum.

Cardiovascular Health

Stress, poor diet and sedentary lifestyles are common today. It's no wonder why heart disease remains the number one killer. Obviously, positive lifestyle changes can help reverse the problems, but nature has created a cavalry to come to the rescue, antioxidants. Antioxidants, each playing a key role in cardiovascular health. Grape skin and grape seed extracts are a rich source of powerful Polyphenols, Resveritrol and Anthocyanins. Along with these extracts, Cranberry and Elderberry, which contain antioxidants as well. Antioxidants neutralize free-radicals, the main cause of cellular and organ damage

Hormonal Balance

The hormonal or endocrine system controls everything from hot flashes to testosterone levels, from metabolic function to repair and regeneration cycles of our cells. As we age, the hormonal levels change and the ability to repair and regenerate is reduced. Colostrum contains FGF & IGF - 1 and other growth factors that help balance the hormonal system and aid in supporting the repair process in the body.

Gastrointestinal Health

Stomach ailments are among the top complaints from patient to doctor. Over 70% of the immune system resides in the gastrointestinal tract. IGF in colostrum promotes normal gastrointestinal function as does Fucoidan, Cranberry and Elderberry.

Neurological Health

Mood, memory and clear mental focus, these are all functions of your neurological system. In 1996, researchers discovered that 8 Essential Sugars called Glyconutrients were responsible in part for normal cell-to-cell communication.

Osteoporosis and Arthritis

Osteoporosis and arthritis are just two examples of age related maladies that affect this system. Patented Sacred Lotus Seed extract contains an enzyme, Methyl Transferase (MT) that helps repair protein and collagen, the building blocks of joints, muscle and bone. IGF from colostrum helps to stimulate increased lean muscle mass.

Fucoidan Widely Studied Around the World

The benefits of Fucoidan have been reported in over 700 scientific studies worldwide. Fucoidan has been shown to promote optimal health utilizing a variety of pathways: Fucoidans optimize the natural killer cell (NK) function, your first line of immune defense.

Laminaria Japonica - The Queen of Seaweeds

Although there are many types of seaweeds around the coasts of the Pacific Ocean, it is the species Laminaria Japonica that has been shown to have the greatest healing benefits. The reason for its miraculous healing properties is its concentration of a specific fucoidan known as U-Fucoidan. Other healing compounds stored in this most beneficial seaweed are antioxidants, including polyphenols, amino acids, essential fatty acids including DHA, essential glyconutrients, organic minerals, vitamins; especially B12, live plant enzymes, alginates for detoxification of heavy metals and laminarin shown to reduce abnormal blood clotting.

Glyconutrients - Sugars that heal

The Greek word “glyco” means “sweet”. Hence, “glyconutrients” means “sweet nutrient”. (Glyconutrients are complex sugars). In 1996, eight glyconutrients were identified to be involved in the cellular communication processes. The essential glyconutrients facilitate cell to cell communication, support the immune system, and promote proper functioning of the nervous and endocrine system. Glyconutrients are important factors in keeping the cardiovascular system functioning at an optimum level. They aid the body in keeping cholesterol and triglycerides in normal healthy ranges. Glyconutrients have been shown to increase endurance, enhance reproductive function and reverse infertility. They also support healthy skin and promote skin firmness. (Mondoa)

Red Cranberries - Big Benefits

Cranberries naturally acidify the urine, and create an environment necessary for a healthy urinary tract, urinary bladder and kidneys. (Ahuja S), A recent study suggests that antioxidants in cranberry extracts are beneficial for healthy cardiovascular system, immune system, and skin. (Wilson T)

Red Grape Skin & Red Grape Seeds - Powerful Antioxidants

Red wine has long been touted for its cardiovascular health benefits. Now, new research reveals that the grapes from which wine is made contain antioxidant compounds that may effectively lower cholesterol and triglycerides. Red wine is a rich source of Polyphenols, Resveratrol, Pterostilbene and Anthocyanins. Grapes also contain vitamin C, lutein, and zeaxanthin, compounds that are necessary for healthy heart and clean arteries. (Rimando, A. M.)

Antioxidant benefits include the following:

Lo Han Kuo - The Fruit of Longevity

Lo Han Kuo fruit belongs to the melon family and is a native to Asia, where it is consumed on a daily basis. It is a rich source of glyconutrients, and it is 250 times sweeter than refined sugar, with no effect on blood sugar. (Zhongyao)

Sacred Lotus Seed

Long revered in Asia for its “age-defying” qualities, this seed has been found to:




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Collection of peer-reviewed and published academic papers.