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Thoughts about Limuplex

By Mark Kelly, Heartsring.net

The list of ingredients indicated on the Limuplex packaging does not include stated amounts contained within the Limuplex powder. The clinical research provide here does indicate the effectiveness of these individual constituents, however there is no "peer-reviewed" research that similarly reflects the effectiveness of the Limuplex formula taken in it's entirety. The lack of stated "active ingredient" amounts contained within Limuplex, leaves both health professionals and consumers guessing at the theraputic amounts required to alliviate various health conditions as promoted by the makers of Limuplex, Dr. Ria Gilday

Unanswered Questions About Dr. Gilday, The Maker of LimuPlex

1. Licensed Certified Nutritionist:
   
   Actively certified in which state?
   
2. Naturopathic Doctor
   
   Actively liscensed in which state?
   
3. Conducted nutrition related cancer Research at Fox Chase Cancer Institute in Philadelphia, PA.
   
   Where the results of this research ever published?

Also I have questions about several of the medical advisory board member credentials found here. Once I get some answers I'll post them on this page.

Mark's Note: I've taken Limuplex for several months. Althought I began, free of any health issues, I did feel an increase sense of wellbeing and focus providing more energy with less sleep. However my general "wellbeing" effects hold little weight when a consumer is trying to make an informed desicion effecting there own health or the health of loved ones.

Below is the marketing material provided by the makers of LimuPlex

LimuPlex Promotes a Broad Range of Health Effects

Immune System Support

In the age of "super bugs" and stress related illness, a healthy immune system has never been more important. LimuPlex contains the combined immune enhancing power of Limu and Colostrum, as research gives evidence to their immune enhancing effects.

Cardiovascular Health

Stress, poor diet and sedentary lifestyles are common today. It's no wonder why heart disease remains the number one killer. Obviously, positive lifestyle changes can help reverse the problems, but nature has created a cavalry to come to the rescue, antioxidants. LimuPlex contains a variety of antioxidants, each playing a key role in cardiovascular health. Grape skin and grape seed extracts are a rich source of powerful Polyphenols, Resveritrol and Anthocyanins. Along with these extracts, LimuPlex contains Cranberry and Elderberry, which contain additional antioxidants. Antioxidants neutralize free radicals, the main cause of cellular and organ damage

Hormonal Balance

The hormonal or endocrine system controls everything from hot flashes to testosterone levels, from metabolic function to repair and regeneration cycles of our cells. As we age, the hormonal levels change and the ability to repair and regenerate is reduced. Colostrum contains FGF & IGF - 1 and other growth factors that help balance the hormonal system and aid in supporting the repair process in the body.

Gastrointestinal Health

Stomach ailments are among the top complaints from patient to doctor. Over 70% of the immune system resides in the gastrointestinal tract. The immune components of LimuPlex alone are a tremendous aid to gastrointestinal and urinary tract health. IGF in colostrum promotes normal gastrointestinal function as does Fucoidan, Cranberry and Elderberry.

Neurological Health

Mood, memory and clear mental focus, these are all functions of your neurological system. In 1996, researchers discovered that 8 Essential Sugars called Glyconutrients were responsible in part for normal cell-to-cell communication. LimuPlex is one of the few food sources for all 8 Essential Glyconutrients. The effect; improved mood, mental clarity and focus.

Osteoporosis and Arthritis

Osteoporosis and arthritis are just two examples of age related maladies that affect this system. Many of the nutrients in LimuPlex help to promote healthier joints and greater physical strength. Patented Sacred Lotus Seed contains an enzyme, Methyl Transferase (MT) that helps repair protein and collagen, the building blocks of joints, muscle and bone. IGF from colostrum helps to stimulate increased lean muscle mass.

LimuPlex is a delicious Berry flavored drink. Pour one scoop of the powder into a glass, add water and watch the lightly effervescent bubbles go to work. They release the isotonic/electrolyte delivery system used in sports drinks to rapidly assimilate the nutrients into the blood stream. LimuPlex is free of preservatives, additives, artificial colors and flavors. LimuPlex is sweetened with Lo Han Kuo, a nutrient dense Chinese fruit.

Fucoidan Widely Studied Around the World

The benefits of Fucoidan have been reported in over 700 scientific studies worldwide. Fucoidan has been shown to promote optimal health utilizing a variety of pathways: Fucoidans optimize the natural killer cell (NK) function, your first line of immune defense. Fucoidan promotes a healthy immune response by increasing macrophage production, and enhancing its phagocytic activity which help the body get rid of viruses, bacteria, fungus, and parasites. (Ponce NM), (Khotimchenko IuS), (Angstwurm K), (Schaeffer DJ) Fucoidan helps to maintain healthy upper respiratory mucous membranes which when weakened may increase the incidence of Bronchitis, Asthma, Chronic Obstructive Pulmonary Disease (COPD) and other pulmonary diseases. (Davis TA) Fucoidan strengthens the mucosal lining of the digestive and urinary tracts. (Mourao PA). Fucoidan is a powerful free-radical neutralizer. (Davis TA) Fucoidan is important for normal blood sugar level, and to support liver function. (Davis TA) Fucoidan is important for healthy hair, nails and skin tone. (Davis TA)

Laminaria Japonica - The Queen of Seaweeds

Although there are many types of seaweeds around the coasts of the Pacific Ocean, it is the species Laminaria Japonica that has been shown to have the greatest healing benefits. The reason for its miraculous healing properties is its concentration of a specific fucoidan known as U-Fucoidan. Other healing compounds stored in this most beneficial seaweed are antioxidants, including polyphenols, amino acids, essential fatty acids including DHA, essential glyconutrients, organic minerals, vitamins; especially B12, live plant enzymes, alginates for detoxification of heavy metals and laminarin shown to reduce abnormal blood clotting.

Glyconutrients - Sugars that heal

The Greek word “glyco” means “sweet”. Hence, “glyconutrients” means “sweet nutrient”. (Glyconutrients are complex sugars). In 1996, eight glyconutrients were identified to be involved in the cellular communication processes. The essential glyconutrients facilitate cell to cell communication, support the immune system, and promote proper functioning of the nervous and endocrine system. Glyconutrients are important factors in keeping the cardiovascular system functioning at an optimum level. They aid the body in keeping cholesterol and triglycerides in normal healthy ranges. Glyconutrients have been shown to increase endurance, enhance sexual function and reverse infertility. They also support healthy skin and promote skin firmness. (Mondoa)

Red Cranberries - Big Benefits

Cranberries naturally acidify the urine, and create an environment necessary for a healthy urinary tract, urinary bladder and kidneys. (Ahuja S), A recent study suggests that antioxidants in cranberry extracts are beneficial for healthy cardiovascular system, immune system, and skin. (Wilson T)

Red Grape Skin & Red Grape Seeds - Powerful Antioxidants

Red wine has long been touted for its cardiovascular health benefits. Now, new research reveals that the grapes from which wine is made contain antioxidant compounds that may effectively lower cholesterol and triglycerides. Red wine is a rich source of Polyphenols, Resveratrol, Pterostilbene and Anthocyanins. Grapes also contain vitamin C, lutein, and zeaxanthin, compounds that are necessary for healthy heart and clean arteries. (Rimando, A. M.)

Antioxidant benefits include the following:

• Supports healthy cardiovascular system, and promotes optimal blood flow (Kiziltepe U)
• Protects DNA and RNA from free-radical damage (Fu ZD)
• Strengthens the Immune system (Cao Z), (Zhang S)
• Demonstrates a non-steroidal, and anti-inflammatory activity (Evers DL), (Donnelly LE)
• Supports healthy female endocrine system (Donnelly LE)
• Provides support for proper vision (Davis TA)
• Protects brain and nerves from oxidative (free-radical) damage (Fu ZD)

Lo Han Kuo - The Fruit of Longevity

Lo Han Kuo fruit belongs to the melon family and is a native to Asia, where it is consumed on a daily basis. It is a rich source of glyconutrients, and it is 250 times sweeter than refined sugar, with no effect on blood sugar. (Zhongyao)

Sacred Lotus Seed* - The Ancient Secret of Youth

Long revered in Asia for its “age-defying” qualities, this seed has been found to:

• Nourish the heart
• Maintain healthy blood flow
• Aid tranquility
• Improve sleep
• Promote healthy digestion
• Support healthy connective tissue and skin tone

Nutraceutical Supplement Research

• Carotenoids
• Colostrum
• Cranberry
• Elderberry Extract
• Fucoidans, Alginates, Laminarines
• Glyconutrients
• Lo Han Kuo
• Lotus Seed
• Polyphenols
• Antimicrobial Peptides
• Xanthones

Sea Vegetable Extracts - Fucoidans, Alginates, Laminarines

Polysaccharide found in the seaweed kombu, U-fucoidan, discovered to cause cancer cells to self-destruct Biomedical Research Laboratories of Takara Shuzo (CEO Hisashi Omiya) and Research Institute for Glycotechnology Advancement, a company funded by the Bio-oriented Technology Research Institute (CEO: Kazue Fukushi), have discovered that a polysaccharide known as U-fucoidan, which is found in kombu and other types of brown seaweed (wakame, mozuku, Limu and hijiki) , causes various types of established cancer cell lines to self-destruct. - www.takara-bio.co.jp

Fucoidans role in macrophage stimulation
. Mytar B, Woloszyn M, Macura-Biegun A, Hajto B, Ruggiero I, Piekarska B, Zembala M. Anticancer Res. 2004 Jul- Aug;24(4):2287-93. PMID: 15330174

Anti-tumor activity and immune response of fucoidan.
Maruyama H, Tamauchi H, Hashimoto M, Nakano T. In Vivo. 2003 May-Jun;17(3):245-9. PMID: 12929574

Preventive effects of fucoidan against Helicobacter pylori infection.
Shibata H, Iimuro M, Uchiya N, Kawamori T, Nagaoka M, Ueyama S, Hashimoto S, Yokokura T, Sugimura T, Wakabayashi K. Helicobacter. 2003 Feb;8(1):59-65. PMID: 12603617

Fucoidan expresses anti-tumor properties.
Koyanagi S, Tanigawa N, Nakagawa H, Soeda S, Shimeno H. Biochem Pharmacol. 2003 Jan 15;65(2):173-9. PMID: 12504793

Fucoidan studied in breast cancer.
Liu JM, Haroun-Bouhedja F, Boisson-Vidal C. Anticancer Res. 2000 Sep-Oct;2000(5A):3265-71. PMID: 11062752

Fucoidans block angiogenesis, and prevent tumor spread.
Zugmaier G, Favoni R, Jaeger R, Rosen N, Knabbe C. Ann N Y Acad Sci. 1999;886:243-8. PMID: 10667230

Anti-tumor and anti-proliferative effects of a fucoidans.
Riou D, Colliec-Jouault S, Pinczon du Sel D, Bosch S, Siavoshian S, Le Bert V, Tomasoni C, Sinquin C, Durand P, Roussakis C. Anticancer Res. 1996 May-Jun;16(3A):1213-8. PMID: 8702239

Fucoidan inhibits lung metastasis.
Itoh H, Noda H, Amano H, Ito H. Anticancer Res. 1995 Sep- Oct;15(5B):1937-47. PMID: 8572581

Anti-tumor active fucoidan from the brown seaweed.
Zhuang C, Itoh H, Mizuno T, Ito H. Biosci Biotechnol Biochem. 1995 Apr;59(4):563-7. PMID: 7772818

Fucoidan inhibits lung carcinoma.
Soeda S, Ishida S, Shimeno H, Nagamatsu A. Jpn J Cancer Res. 1994 Nov;85(11):1144-50. PMID: 7829400

Antimetastetic effect of fucoidan.
Soeda S, Ishida S, Honda O, Shimeno H, Nagamatsu A. Cancer Lett. 1994 Sep 30;85(1):133-8. PMID: 7923097

Anti-tumor activity of fucoidan.
Itoh H, Noda H, Amano H, Zhuaug C, Mizuno T, Ito H. Anticancer Res. 1993 Nov-Dec;13(6A):2045-52. PMID: 8297113

Anti blood clotting and antimetastetic effect of fucoidan.
Maruyama H, Nakajima J, Yamamoto I. Kitasato Arch Exp Med. 1987 Sep;60(3):105-21. No abstract available. PMID: 2455094

Anti-tumor activity of fucoidan.
Chida K, Yamamoto I. Kitasato Arch Exp Med. 1987 Jun;60(1- 2):33-9. No abstract available. PMID: 3669501

Inhibition of tumor metastasis.
Coombe DR, Parish CR, Ramshaw IA, Snowden JM. Int J Cancer. 1987 Jan 15;39(1):82-8. PMID: 2878892

Anti-tumor effect of seaweeds.
Yamamoto I, Takahashi M, Suzuki T, Seino H, Mori H. Jpn J Exp Med. 1984 Aug;54(4):143-51. PMID: 6513098

Laminaria and mammary (breast) cancer in rats.
Teas J, Harbison ML, Gelman RS. Cancer Res. 1984 Jul;44(7):2758-61. PMID: 6426785

Fucoidan ad brain lesions.
da Cruz LA, Cruz TF, Moscarello MA. Cell Adhes Commun. 1993 May;1(1):9-20. PMID: 7521750

Laminaria japonica converts inorganic minerals into organic minerals.
Yan X, Zheng L, Chen H, Lin W, Zhang W. J Agric Food Chem. 2004 Oct 20;52(21):6460-6464. PMID: 15479007

Laminaria japonica protects liver in induced diabetes.
Jin DQ, Li G, Kim JS, Yong CS, Kim JA, Huh K. Biol Pharm Bull. 2004 Jul;27(7):1037-40. PMID: 15256736

Effects of fucoidan on chronic renal failure in rats.
Zhang Q, Li Z, Xu Z, Niu X, Zhang H. Planta Med. 2003 Jun;69(6):537-41. PMID: 12865973

Laminaria expresses antibacterial activity.
Colin C, Leblanc C, Wagner E, Delage L, Leize-Wagner E, Van Dorsselaer A, Kloareg B, Potin P. J Biol Chem. 2003 Jun 27;278(26):23545-52. Epub 2003 Apr 15. PMID: 12697758

Fucoidans from Laminaria inhibits the human T cell lymphotropic virus.
Romanos MT, Andrada-Serpa MJ, Mourao PA, Yoneshigue- Valentin Y, Costa SS, Pereira MS, Miranda MM, Goncalves JL, Wigg MD. Antivir Chem Chemother. 2002 Jul;13(4):219-21. PMID: 12495209

Free radical scavenging effect of Laminaria japonica.
Han J, Kang S, Choue R, Kim H, Leem K, Chung S, Kim C, Chung J. Fitoterapia. 2002 Dec;73(7-8):710-2. PMID: 12490237

Free radical scavenging effect of Laminaria japonica.
Kupper FC, Muller DG, Peters AF, Kloareg B, Potin P. J Chem Ecol. 2002 Oct;28(10):2057-81. PMID: 12474900

Alginate affects on blood sugar in humans with diabetes.
Torsdottir I, Alpsten M, Holm G, Sandberg AS, Tolli J. J Nutr. 1991 Jun;121(6):795-9. PMID: 1851824

Alginates bind heavy metals.
Arica MY, Bayramoglu G, Yilmaz M, Bektas S, Genc O. J Hazard Mater. 2004 Jun 18;109(1-3):191-9. PMID: 15177759

Alginate for chronic wounds.
Ziegler UE, Schmidt K, Keller HP, Thiede A. Fortschr Med Orig. 2003;121(1):19-26. German. PMID: 15117065

Alginates bind heavy metals.
Davis TA, Llanes F, Volesky B, Diaz-Pulido G, McCook L, Mucci A. Appl Biochem Biotechnol. 2003 Aug;110(2):75-90. PMID: 14515023

Alginates bind heavy metals.
Pandey AK, Pandey SD, Misra V, Devi S. J Hazard Mater. 2003 Mar 17;98(1-3):177-81. PMID: 12628785

Fucoidan may benefit diabetics.
Tamura Y, Adachi H, Osuga J, Ohashi K, Yahagi N, Sekiya M, Okazaki H, Tomita S, Iizuka Y, Shimano H, Nagai R, Kimura S, Tsujimoto M, Ishibashi S. J Biol Chem. 2003 Apr 11;278(15):12613- 7. Epub 2002 Dec 06. PMID: 12473645

Sea weeds supplementation lowers blood glucose and supports antioxidant systems in rats.
Lee KS, Choi YS, Seo JS. J Med Food. 2004 Summer;7(2):130-5. PMID: 15298757

Nutraceuticals Resources

Nutraceuticals World
Nutraceuticals World is a bimonthly trade magazine focusing on manufacturers of dietary supplements, functional foods and nutritional beverages.

The Nutraceutical Institute Nutraceutical Overview, Rutgers, The State University of New Jersey and St. Joseph's, Philadelphia's Jesuit University

American Nutraceutical Association Develops and provides educational materials and programs on nutraceuticals and nutrition for health care professionals, consumers.

More Nutraceutical & Dietary Supplement Resources

Glyconutrients Research

Glyconutrients and diabetics.
Lloyd P;Hockaday TD;Randle PJ Diabetologia. 1984 Oct; 27: 433- 436.

Glyconutrients benefit diabetics.
Morgan LM;Wright JW;Marks V;. Diabetologia. 1979 Apr; 16: 235- 239.

Glyconutrients effect carbohydrate transport in humans.
Martin A;Rambal C;Berger V;. Biochimie. 1998; 80: 75-86.

Glyconutrients effect carbohydrate transport in rats.
Sykes S;Morgan LM;English J;Marks V;. J Endocrinol. 1980 May; 85: 201-207.

Glyconutrients stimulate macrophage activity.
Takata I;Chida K;Gordon MR;. J Leukoc Biol. 1987 Mar; 41: 248- 256.

Glyconutrients effect on metastatic tumors.
Warczynski P;Gil J;Szmigielski S;Beuth J;Pulverer G;. Anticancer Res. 1997 Mar; 17: 1223-1226.

Glyconutrients effect on metastatic liver tumors.
Isenberg J;Stoffel B;Stutzer H;Otte K;Beuth J;. Anticancer Res. 1997 Sep; 17: 3767-3772.

Glyconutrients effect on metastatic liver tumors.
Kelly GS;.. Altern Med Rev. 1999 Apr; 4: 96-103.

Lo Han Kuo

Lo Han Kuo - possesses many advantages.
Mu J. Zhonghua Kou Qiang Yi Xue Za Zhi. 1998 May;33(3):183-5. Chinese. PMID: 11774428

Lo Han Kou –effectively inhibited Epstein-Barr Virus.
Ukiya M, Akihisa T, Tokuda H, Toriumi M, Mukainaka T, Banno N, Kimura Y, Hasegawa J, Nishino H.
J Agric Food Chem. 2002 Nov 6;50(23):6710-5. PMID: 12405766

Research on Cranberry

A flavonoid fraction from cranberry extract inhibits proliferation of human tumor cell lines.
Ferguson PJ, Kurowska E, Freeman DJ, Chambers AF, Koropatnick DJ. J Nutr. 2004 Jun;134(6):1529-35. PMID: 15173424

Cranberry extract effective in urinary tract infections.
Waites KB, Canupp KC, Armstrong S, DeVivo MJ. J Spinal Cord Med. 2004;27(1):35-40. PMID: 15156935

Cranberry extract effects against human tumor cells.
Seeram NP, Adams LS, Hardy ML, Heber D. J Agric Food Chem. 2004 May 5;52(9):2512-7. PMID: 15113149

Cranberry extract shows antioxidant, and anti-carcinogenic properties.
Bagchi D, Sen CK, Bagchi M, Atalay M. Biochemistry (Mosc). 2004 Jan;69(1):75-80. PMID: 14972022

Cranberry extract shows antioxidant, and anti-carcinogenic properties.
Yan X, Murphy BT, Hammond GB, Vinson JA, Neto CC. J Agric Food Chem. 2002 Oct 9;50(21):5844-9. PMID: 12358448

Cranberry extract reduced attachment of E coli.
Allison DG, Cronin MA, Hawker J, Freeman S. J Basic Microbiol. 2000;40(1):3-6. PMID: 10746194

Cranberry extract powerful antioxidant.
Wilson T, Porcari JP, Harbin D. Life Sci. 1998;62(24):PL381-6. PMID: 9627085

Cranberry extract have potential anti cancer property.
Bomser J, Madhavi DL, Singletary K, Smith MA. Planta Med. 1996 Jun;62(3):212-6. PMID: 8693031

Elderberry Extract

Elderberry extract offer an efficient, safe and cost-effective treatment for influenza.
Zakay-Rones Z, Thom E, Wollan T, Wadstein J. J Int Med Res. 2004 Mar-Apr;32(2):132-40. PMID: 15080016

Elderberry extract - effective against Influenza A and B.
Zakay-Rones Z, Varsano N, Zlotnik M, Manor O, Regev L, Schlesinger M, Mumcuoglu M. J Altern Complement Med. 1995 Winter;1(4):361-9. PMID: 9395631

Elderberry significant decreased cholesterol.
Murkovic M, Abuja PM, Bergmann AR, Zirngast A, Adam U, Winklhofer-Roob BM, Toplak H. Eur J Clin Nutr. 2004 Feb;58(2):244-9. PMID: 14749743

Elderberry extract offer an anti-inflammatory benefit.
Barak V, Birkenfeld S, Halperin T, Kalickman I. Isr Med Assoc J. 2002 Nov;4(11 Suppl):919-22. PMID: 12455180

Elderberry extract powerful antioxidant.
Roy S, Khanna S, Alessio HM, Vider J, Bagchi D, Bagchi M, Sen CK. Free Radic Res. 2002 Sep;36(9):1023-31. PMID: 12448828

Anecdotal reports: Elderberry reduces viral of HIV load to non-detectable levels.
[No authors listed] Posit Health News. 1998 Fall(No 17):7-11. PMID: 11366557

Elderberry extract powerful antioxidant.
Youdim KA, Martin A, Joseph JA. Free Radic Biol Med. 2000 Jul 1;29(1):51-60. PMID: 10962205

Lotus Seed

Lotus seed has unique properties to repair itself even in dark,dry places.
Ushimaru T, Hasegawa T, Amano T, Katayama M, Tanaka S, Tsuji H. J Plant Physiol. 2003 Mar;160(3):321-4. PMID: 12749089