"Alternative Disease Approach," Vitamins C and E
By Wendy Wells, NMD.
Researchers at Oregon State University's, Linus Pauling Institute have been working to answer questions about how nutrition, and disease are connected. Their work, appearing in the May 2011 journal of Free Radical Biology and Medicine, examines the mechanistic pathways of two dietary antioxidants, vitamins C, and E.
Previous research documents how each of these vitamins are necessary for human health since diet and supplements are the only source of intake for these essential nutrients. To help identify the molecular steps of ascorbic acid (vitamin C), and alpha tocopherol (vitamin E), researchers present evidence to demonstrate essential cofactors, biosynthesis, and gene transcription factors, responsible for regulating tumor cell growth, energy metabolism, and white blood cell functions. Also, an example is given how vitamin C plays a role in the synthesis of skin collagen.
Since vitamin C shows a dose dependent regulation of HIF (hypoxia-inducible factor) pathways, regulating the oxygen levels in our tissues, OSU researchers suggest how vitamin C and E offers, "alternative," and "additional approaches," for controlling cancer progression, viral infections, and inflammation.
Alpha-tocopherol (Vitamin E), is described as an essential fat-soluble antioxidant, capable of scavenging and neutralizing toxic free-radicals in fatty tissues. Vitamin E deficiencies, observed in human symptoms, suggest that it's antioxidant properties have a major influence on the protection of blood cell membranes, and nerve tissue.
Vitamin C Provides:
- Protection against oxidative stress-induced cellular damage
- Neutralization of free-radicals in fat lipids, that is vitamin E-dependent
- Protection of proteins from lipid oxidization by-products
- Inflammation is also considered, as vitamin C plays a role in recycling nitric oxide, responsible for arterial elasticity and controlling blood pressure levels.
In this paper, Oregon State University researchers discuss the effects of Vitamin C, and E, by emphasizing clinical biomarker results from randomized, placebo-controlled studies. - Free Radical Biology and Medicine, May 2011. PMID:21664268
I have a comment about how much and which form of each vitamin are best. My daily recommendation for Vitamin E is typically 400IU of MIXED tocopherols. Not all brands of vitamin E supplements have a mixture of the tocopherols. For Vitamin C, I recommend BUFFERED forms, such as Calcium or Sodium Ascorbate. I like this form over the “ascorbic acid” form because it does not make the body more acidic. As for how much Vitamin C to take on a daily basis, we all are different. To find out, take the Vitamin C Bowel Tolerance Test. The amount we need per day depends on how much cellular damage and repair that is happening in our bodies. For example, someone who just had surgery needs ten times the amount she would need normally. One who is highly stressed, needs more vitamin C than someone who is not stressed. Also, Vitamin E and Vitamin C have been shown to keep each other working, so it is beneficial to take them together with a meal if possible.
I have watched skin change dramatically over a short time with IV vitamin C. Here is a site talking about putting a poultice of vitamin c directly on the skin. Cancer Tutor And here's site with good references to vitamin C IV for cancer. Naturemed Clinic.
Ascorbic acid concentrations selectively kill cancer cells
Researchers demonstrate how hydrogen peroxide is delivered to cancer tissues through the use of ascorbic acid. Their findings give plausibility to intravenous ascorbic acid in cancer treatments, as well as, provide unexpected implications for treatment of infections where hydrogen peroxide may be beneficial. Source: PNAS September, 2005 102:38
1. Vitamins and trace elements: practical aspects of supplementation. PMID:16928476
2. Effects of nutrients (in food) on the structure and function of the nervous system: update on dietary requirements for brain. PMID:17066209
"Alternative" approaches include vitamins C&E, shown to reduce cancer inflammation.